Chemokine receptor CCR2 is not essential for the development of experimental cerebral malaria.
نویسندگان
چکیده
Infection with Plasmodium berghei ANKA induces cerebral malaria in susceptible mice. Brain-sequestered CD8(+) T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine receptor expressed on CD8(+) T cells. Infected CCR2-deficient mice were as susceptible to cerebral malaria as wild-type mice were, and CD8(+) T-cell migration to the brain was not abolished.
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ورودعنوان ژورنال:
- Infection and immunity
دوره 71 6 شماره
صفحات -
تاریخ انتشار 2003